Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Transition-metal-catalyzed Electrophilic Activation of 1,1-Difluoro-1-alkenes: Oxindole Synthesis via Intramolecular Amination
Hiroyuki TanabeJunji Ichikawa
Author information
JOURNALS RESTRICTED ACCESS

2010 Volume 39 Issue 3 Pages 248-249

Details
Abstract

In the presence of a catalytic amount of palladium(II) chloride, β,β-difluorostyrenes bearing a sulfonamido group at the ortho position were treated with trimethylsilyl trifluoromethanesulfonate to afford oxindoles in high yield. The reactions proceeded via 5-endo-trig cyclization, hydrolysis, and desulfonylation. This sequence allowed the transformation of difluorostyrenes into free oxindoles in a one-pot operation.

Information related to the author

This article cannot obtain the latest cited-by information.

© 2010 The Chemical Society of Japan
Previous article Next article
feedback
Top