Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
Letter
Virus Capsid Coating of Gold Nanoparticles via Cysteine–Au Interactions and Their Effective Cellular Uptakes
Keita NagakawaKenichi NiikuraTadaki SuzukiYasutaka MatsuoManabu IgarashiHirofumi SawaKuniharu Ijiro
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2012 Volume 41 Issue 1 Pages 113-115

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Abstract

This manuscript describes the synthesis of virus capsid protein-coated Au nanoparticle (VP–AuNP) without the use of the inherent self-assembly of virus proteins into virus particles. Covalent binding between Au and cysteines in the virus proteins keep the cell-surface binding sites on the external surface. Based on this method, various sizes of VP–AuNP can be created in a similar manner to native virus particles. We clarified the optimum size of the VP–AuNP for internalization into cells.

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© 2012 The Chemical Society of Japan
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