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Chemistry Letters
Vol. 41 (2012) No. 1 P 113-115

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http://doi.org/10.1246/cl.2012.113

Letter

This manuscript describes the synthesis of virus capsid protein-coated Au nanoparticle (VP–AuNP) without the use of the inherent self-assembly of virus proteins into virus particles. Covalent binding between Au and cysteines in the virus proteins keep the cell-surface binding sites on the external surface. Based on this method, various sizes of VP–AuNP can be created in a similar manner to native virus particles. We clarified the optimum size of the VP–AuNP for internalization into cells.

Copyright © 2012 The Chemical Society of Japan

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