Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Special Issue for IACIS2012
Chemodegradable Gemini Alanine-based Cationic Surfactants: Synthesis and Antifungal Activity
Jacek LuczynskiRenata FrackowiakJoanna SzczepaniakAnna Krasowska
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JOURNALS OPEN ACCESS

2012 Volume 41 Issue 10 Pages 1176-1177

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Abstract

The aim of the present study was to synthesize and examine the biological properties of soft gemini bis-quaternary surfactants, derivatives of bis-alanine esters. As a model system for the investigation of the activity of gemini surfactants Candida albicans strains with deletions of gene encoded ABC transporters were used. TMPAL-12Br was more active than TMPAL-10Br in dislodging of the C. albicans biofilms. The results of the present study may prove useful in antifungal applications.

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© 2012 The Chemical Society of Japan
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