Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Cleavage of Supercoiled Plasmid DNA by Phenanthroline–Polyamine Conjugates as a Metal-free Artificial Nuclease
Tomokazu MasudaTakeshi SasagaseAkiko N. OzakiMasayasu KuwaharaHiroaki OzakiHiroaki Sawai
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2013 Volume 42 Issue 1 Pages 86-88

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Abstract

In this study, phenanthroline–polyamine conjugates have been synthesized. The conjugates bind to DNA and hydrolyze it in the absence of any metal and reducing agent under physiological conditions.

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© 2013 The Chemical Society of Japan
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