Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Synthesis of a Heparan Sulfate Disaccharide Fluoride for Detection of Heparanase Activity
Masashi OhmaeYuki FujitaJunko TakadaShunsaku Kimura
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2013 Volume 42 Issue 10 Pages 1168-1169

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Abstract

A novel heparan sulfate disaccharide fluoride derivative of GlcN(SO3Na)α(1 → 4)GlcAβ-F (1) was designed as a probe for detection of heparanase activity. Compound 1 was successfully prepared via 10-step chemical reactions. Human heparanase-1 effectively recognized 1, which induced liberation of the fluoride ion by hydrolysis via enzyme catalysis. The hydrolysis reaction was easily monitored by 1H NMR measurements, in which the signal from H-1 gradually disappeared.

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© 2013 The Chemical Society of Japan
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