Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Switchable Aggregation Phenomena of DNA-conjugated Poly(N-isopropylacrylamide) Driven by Transformation between ssDNA and dsDNA with Control of DNA Charges and Flexibility
Yuuki SugawaraTakanori TamakiHidenori OhashiTakeo Yamaguchi
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2013 Volume 42 Issue 12 Pages 1568-1570

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Abstract

It is possible to switch between the different aggregation phenomena of deoxyribonucleic acid (DNA)-conjugated poly(N-isopropylacrylamide) (PNIPAM) by controlling the balance of DNA charges and flexibility. The shift in the balance between DNA charges and flexibility occurs by changing the salt concentration in polymer solutions and the DNA fraction in polymer chains. Single-stranded DNA (ssDNA)-conjugated PNIPAM was more aggregated than double-stranded (dsDNA) when DNA charges are predominant. In contrast, dsDNA-conjugated PNIPAM was more aggregated than ssDNA when flexibility was predominant.

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© 2013 The Chemical Society of Japan
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