Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
Letter
Imaging Mass Spectrometry of Intravenously Injected Gold Nanorods in Mice
Masanori FujiiNaotoshi NakashimaTakuro NiidomeYasuro Niidome
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JOURNALS OPEN ACCESS

2014 Volume 43 Issue 1 Pages 131-133

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Abstract

Laser-induced desorption and ionization (LDI) of gold ions (Aun+: n = 1–3) were observed from gold nanorods in a liver tissue section (thickness: 10 µm). Larger amounts of gold nanorods produced stronger mass signals. Organic molecules in the tissue were not detected and did not inhibit the LDI processes of the gold nanorods in the tissue. Because of the selective LDI processes of the gold nanorods, the distribution of gold in the liver was successfully determined by imaging mass spectrometry.

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© 2014 The Chemical Society of Japan
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