Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
Letter
Enantioselective Fluorination of β-Ketoesters Catalyzed by Chiral Sodium Phosphate: Remarkable Enhancement of Reactivity by Simultaneous Utilization of Metal Enolate and Metal Phosphate
Keiji MoriAyaka MiyakeTakahiko Akiyama
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2014 Volume 43 Issue 1 Pages 137-139

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Abstract

A highly enantioselective fluorination of β-ketoesters catalyzed by chiral sodium phosphate is achieved. In this process, the simultaneous formation of sodium enolate and sodium phosphate under basic conditions is the key to achieving excellent selectivity. Indanone derivatives as well as benzofuranone derivatives could be employed in this reaction to afford the fluorinated adducts in good yields with good to excellent enantioselectivities.

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© 2014 The Chemical Society of Japan
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