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Chemistry Letters
Vol. 43 (2014) No. 1 P 137-139

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http://doi.org/10.1246/cl.130934

Letter

A highly enantioselective fluorination of β-ketoesters catalyzed by chiral sodium phosphate is achieved. In this process, the simultaneous formation of sodium enolate and sodium phosphate under basic conditions is the key to achieving excellent selectivity. Indanone derivatives as well as benzofuranone derivatives could be employed in this reaction to afford the fluorinated adducts in good yields with good to excellent enantioselectivities.

Copyright © 2014 The Chemical Society of Japan

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