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Chemistry Letters
Vol. 43 (2014) No. 4 P 556-558

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http://doi.org/10.1246/cl.131199

Letter

The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford α-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.

Copyright © 2014 The Chemical Society of Japan

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