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Chemistry Letters
Vol. 44 (2015) No. 12 P 1652-1654

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http://doi.org/10.1246/cl.150802

Letter

Zinc-catalyzed asymmetric α-amination of β-ketocarbonyl compounds 2 using dialkyl azodicarboxylates 3 as the electrophilic nitrogen source is described. The complexes of Zn(OTf)2 and the axially chiral phenanthroline ligands (S)-1 were identified as effective catalysts for this transformation to provide α-amino-β-ketocarbonyl compounds 4 with up to 93% ee.

Copyright © 2015 The Chemical Society of Japan

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