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Chemistry Letters
Vol. 45 (2016) No. 1 P 30-32

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http://doi.org/10.1246/cl.150916

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The formal total synthesis of ezetimibe was accomplished using a proline-mediated, asymmetric, three-component Mannich reaction as the key step. The two stereogenic centers on the β-lactam skeleton of ezetimibe were controlled by the syn-selective asymmetric Mannich reaction, followed by isomerization.

Copyright © 2016 The Chemical Society of Japan

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