Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Fluorescence Quenching of Alexa Fluor 488-labeled DNA by Complementary Trp-containing PNA Partitioned in Liquid-ordered Domains
Yoshimi OkaHisae Shishino
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2017 Volume 46 Issue 11 Pages 1672-1675

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Abstract

We demonstrate Trp-containing PNA/Alexa Fluor 488 (AL488)-labeled DNA hybrid partitions preferentially into liquid-ordered (lo) microdomains of GUV. The Trp quenches the fluorescence of AL488 microscopically. The mechanism involved collisional and static quenching, both of which proceeded effectively. The static quenching indicates an AL488–Trp complex through a stacking interaction.

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© 2017 The Chemical Society of Japan
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