Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Synthesis of Transmembrane Molecules by Click Chemistry
Wataru HatanakaHiroki TakeuchiMinaho KogaTaka-aki RyujinAkihiro KishimuraYoshiki KatayamaShinya TsukijiTakeshi Mori
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2019 Volume 48 Issue 5 Pages 433-436

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Abstract

We report here efficient synthesis of artificial transmembrane molecules (ATMs), via click chemistry of a transmembrane part and membrane-penetrating parts. Synthesized ATMs penetrated the cell membrane by Coulombic force, while they stayed on the cell membrane once they were complexed with streptavidin.

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© 2019 The Chemical Society of Japan
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