Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Letter
Rhodium-catalyzed Synthesis of Benzo[b]thiophene-3-carboxamides via Cyclization of (ortho-Alkynyl)phenyl Sulfides in the Presence of Isocyanates
Akiho MizukamiMaika TsugitaMako ShimoraSaki TanakaNoboru HayamaTetsutaro KimachiKiyofumi Inamoto
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2019 Volume 48 Issue 5 Pages 468-470

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Abstract

A facile synthesis of benzo[b]thiophene-3-carboxamides from (ortho-alkynyl)phenyl methoxymethyl sulfides and isocyanates was realized. The method involves a tandem-type, cyclization–addition sequence in the presence of a rhodium catalyst. The reactions proceed under considerably mild conditions (room temperature to 50 °C), providing an efficient and entirely new route to substituted benzo[b]thiophene-3-carboxamide derivatives.

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© 2019 The Chemical Society of Japan
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