Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Discovery of synthetic methoxy-substituted 4-phenylbutyric acid derivatives as chemical chaperones
Seisuke MimoriYasunobu OkumaMasayuki KanekoKoichi KawadaYasuyuki NomuraYasuoki MurakamiHiroshi Hamana
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JOURNAL RESTRICTED ACCESS Advance online publication

Article ID: 130419


In this study, we evaluated the chemical chaperone activity of synthetic 4-phenylbutyric acid (4-PBA) derivatives. These derivatives have a methoxy group at the benzene ring and/or longer or shorter fatty-acid portions. Several 4-PBA derivatives demonstrated higher anti-aggregation activity than 4-PBA. Moreover, 4-(4-methoxyphenyl)butanoic acid (7b) showed protective effects against endoplasmic reticulum stress-induced neuronal cell death.

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