Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
A NOVEL DECARBOXYLATION OF α-AMINO ACIDS. A FACILE METHOD OF DECARBOXYLATION BY THE USE OF 2-CYCLOHEXEN-1-ONE AS A CATALYST
Mitsunori HashimotoYutaka EdaYasutomo OsanaiToshiaki IwaiSeiichi Aoki
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1986 Volume 15 Issue 6 Pages 893-896

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Abstract

In the presence of a catalytic amount of 2-cyclohexen-1-one, decarboxylation of α-amino acids proceeds smoothly and affords the corresponding amino compounds in good yields. Optically active amino compounds, (3R)-(−)-3-hydroxypyrrolidine and (2R)-(−)-2-hydroxypropylamine are obtained in 93% and 80% yields, respectively.

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