Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Asymmetric Synthesis of 2-Amino Alcohol Derivatives from (S)-α-Amino Aldehydes via Chiral Acetal Templates
Shinzo KanoTsutomu YokomatsuHaruo IwasawaShiroshi Shibuya
Author information
JOURNALS FREE ACCESS

1987 Volume 16 Issue 8 Pages 1531-1534

Details
Abstract

Titanium tetrachloride mediated addition of allyltrimethylsilane to chiral acetals derived from (S)-α-amino aldehydes and (+)-(2S,4S)-pentane-2,4-diol gave the anti-2-amino alcohol derivatives with considerably high diastereoselectivity. On the other hand, the same reaction by the use of acetals obtained from (−)-(2R,4R)-pentane-2,4-diol gave the products of opposite stereochemistry series as major products.

Information related to the author

This article cannot obtain the latest cited-by information.

© The Chemical Society of Japan
Previous article Next article
feedback
Top