Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
Protecting Group for Carboxyl Function. Cleavage of 2-Tosylethyl Esters with Fluoride Ion in Non-aqueous Media
Hironori TsutsuiMasakazu MutoKatsuyuki MotoyoshiOyo Mitsunobu
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1987 Volume 16 Issue 8 Pages 1595-1598

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Abstract

2-Tosylethyl carboxylates reacted with tetrabutylammonium fluoride in tetrahydrofuran at 0 °C for 1 h to give the corresponding free acids in nearly quantitative yields. Under the same conditions, t-butyldimethylsilyl protecting group of secondary alcohols remained intact.

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