Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
SYNTHESIS OF THE MERRIFIELD RESIN ESTERS OF N-PROTECTED AMINO ACIDS WITH THE AID OF HYDROGEN BONDING1
Kusuo HorikiKen’ichi IganoKen Inouye
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JOURNALS FREE ACCESS

1978 Volume 7 Issue 2 Pages 165-168

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Abstract

A synthesis of the Merrifield resin esters of N-protected amino acids was attempted with the aid of hydrogen-bonding property of fluoride ion with carboxylic acids to obtain the esters in satisfactory yields. This will provide an alternatively efficient and economical method for the preparation of the key intermediate of the solid phase peptide synthesis.

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