Chemistry Letters
Online ISSN : 1348-0715
Print ISSN : 0366-7022
ISSN-L : 0366-7022
A NEW METHOD FOR CONFORMATIONAL ANALYSIS OF PEPTIDES BY HYDROGEN–CHLORINE REPLACEMENT REACTION
Michio KondoKouji OkamotoIchiro NishiMakoto YamamotoTetsuo KatoNobuo Izumiya
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1980 Volume 9 Issue 6 Pages 703-704

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Abstract

Replacement reaction of peptide NH with chlorine was applied to the peptide antibiotics, gramicidin S and tuberactinamine N. The rate of chlorination followed by NMR spectra demonstrates that the hydrogen-bonded peptide NH in the molecule is much more susceptible to chlorination than the solvent-exposed peptide NH.

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