Chemical and Pharmaceutical Bulletin
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Kaempferol Acetylrhamnosides from the Rhizome of Dryopteris crassirhizoma and Their Inhibitory Effects on Three Different Activities of Human Immunodeficiency Virus-1 Reverse Transcriptase
Byung-Sun MINMiyuki TOMIYAMAChao-Mei MANorio NAKAMURAMasao HATTORI
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2001 年 49 巻 5 号 p. 546-550

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Three new kaempferol glycosides, called crassirhizomosides A (1), B (2) and C (3), were isolated from the rhizome of Dryopteris crassirhizoma (Aspidiaceae), together with the known kaempferol glycoside, sutchuenoside A (4). The structures of 1-3 were determined as kaempferol 3-α-L-(2, 4-di-O-acetyl)rhamnopyranoside-7-α-L-rhamnopyranoside, kaempferol 3-α-L-(3, 4-di-O-acetyl)rhamnopyranoside-7-α-L-rhamnopyranoside, and kaempferol 3-α-L-(2, 3-di-O-acetyl)rhamnopyranosside-7-α-L-rhamnopyranoside, respectively, by chemical and spectroscopic means. Inhibitory effects of 1-4 and kaempferol on human immunodeficiency virus reverse transcriptase-associated DNA polymerase (RNA-dependent DNA polymerase and DNA-dependent DNA polymerase) and RNase H activities were investigated.

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© 2001 The Pharmaceutical Society of Japan
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