J-STAGE Home  >  Publications - Top  > Bibliographic Information

Chemical and Pharmaceutical Bulletin
Vol. 49 (2001) No. 6 P 711-715



Regular Articles

The C-26 modified monensin derivatives, 26-O-benzoylmonensin (3), 26-O-benzylmonensin (4) and 26-phenylaminomonensin (5) were prepared from monensin (1). Na+ ion transport activity through biological membrane and antibacterial activity of 3-5 were evaluated and compared with the activities reported for a 26-phenylurethane derivative (2). Among these compounds, 5 showed the largest Na+ ion transport and antibacterial activities. In these compounds, the formation of head-to-tail hydrogen bonds was suggested to be an important factor for Na+ ion transport and antibacterial activities.

Copyright © 2001 The Pharmaceutical Society of Japan

Article Tools

Share this Article