Chemical Modification of Coumarin Dimer and HIV-1 Integrase Inhibitory Activity

Pili Chih-Min Mao; Jean-Francois Mouscadet; Herve Leh; Christian Auclair; Ling-Yih Hsu

doi:10.1248/cpb.50.1634

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

Notes

Chemical Modification of Coumarin Dimer and HIV-1 Integrase Inhibitory Activity

Pili Chih-Min Mao, Jean-Francois Mouscadet, Herve Leh, Christian Auclair, Ling-Yih Hsu

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Keywords: chemical modification, coumarin dimmer, HIV-1 integrase, inhibitor

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Volume 50 (2002) Issue 12 Pages 1634-1637

DOI https://doi.org/10.1248/cpb.50.1634

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Abstract

A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent inhibitory activities.

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