Pharmacological Studies and Synthesis of Morpholino Alkyl Derivatives

Abstract

Seven morpholin derivatives were synthesized (compounds 1—7) and their behavioural effects were evaluated; the elements considered were locomotor activity, motor coordination, catalepsy, stereotyped behaviour and antinociception. All the compounds, at doses of 10—20—40 mg/kg/i.p., induced a reduction of all behavioural elements without a significant antinociceptive effect. These results indicate that these morpholin derivatives affect the central nervous system.