N-Substituted Hydroxyureas as Urease Inhibitors

Shinichi Uesato; Yuichiro Hashimoto; Masaru Nishino; Yasuo Nagaoka; Hiroshi Kuwajima

doi:10.1248/cpb.50.1280

Notes

N-Substituted Hydroxyureas as Urease Inhibitors

Shinichi Uesato, Yuichiro Hashimoto, Masaru Nishino, Yasuo Nagaoka, Hiroshi Kuwajima

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Keywords: urease inhibitor, N-hydroxy-N′-(m-methylphenyl)urea, Helicobacter pylori, jack bean

JOURNAL FREE ACCESS

2002 Volume 50 Issue 9 Pages 1280-1282

DOI https://doi.org/10.1248/cpb.50.1280

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Abstract

In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.

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