Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Arylnaphthalide Lignans from Cleistanthus collinus
Chimmani RameshNasi RavindranathTejomoortula Siva RamBiswanath Das
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2003 Volume 51 Issue 11 Pages 1299-1300

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Abstract

Chemical examination of the aerial parts of Cleistanthus collinus afforded the arylanphthalide lignans, cleistanone (1), diphyllin (2), cleistanthins A (3), C (4) and D (5), and 4-O-(3″-O-methyl-β-D-glucopyranosyl)-diphyllin (6). The first compound is a new member of the rare group of arylnaphthalide lignans containing an alkoxy group on the lactone ring. The structure of the compound was determined from its spectral data, chemical transformations and partial synthesis from diphyllin (2). The new lignan, 1 and its acetyl derivative, 7 were found to exhibit cytotoxicity against MT2 cell lines.

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© 2003 The Pharmaceutical Society of Japan
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