Tosylation of Endocrine-Disruptive Alkylphenolic Compounds in a Solid-Phase Reaction System Consisting of C₁₈-Modified Silica Gel and Aqueous Buffer Solution

Abstract

The tosylation reaction of endocrine-disruptive alkylphenolic compounds in a solid-phase aqueous system was investigated with the aim of developing an environment-friendly and efficient derivatization method for HPLC analyses of environmental samples. The phenols were rapidly and efficiently converted to the tosyl derivatives on a commercially available ODS solid-phase cartridge by passing an aqueous buffer solution through it. The solid-phase aqueous tosylation system has been incorporated into a preconcentration step performed by solid-phase extraction from environmental water.