Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Notes
New Labdane Diterpenes from the Stem Bark of Larix laricina
André PichetteSerge LavoiePierre MorinVakhtang MshvildadzeMaxime LebrunJean Legault
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2006 Volume 54 Issue 10 Pages 1429-1432

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Abstract

Two new labdane diterpenes, cis-19-hydroxyabienol (1) and 8α-hydroxy-12Z,14-labdadien-19-al (2), along with another labdane described for the first time in the genus Larix, 19-acetoxy-13S-hydroxy-8(17),14-labdadiene (3) and a stilbene, 3-methoxy-3,3′,5′-trihydroxystilbene (4), were isolated from the stem bark of Larch (Larix laricina). Their structures were established by standard chemical and spectroscopic methods. Compounds 2 and 3 were shown to be moderately cytotoxic against A-549, DLD-1 and normal skin fibroblast cell lines, WS1. Compound 1 was found to be selectively active against colon carcinoma cell lines, DLD-1.

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© 2006 The Pharmaceutical Society of Japan
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