Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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COX-1, COX-2 Inhibitors and Antifungal Agents from Croton hutchinsonianus
Sirivan AthikomkulchaiHunsa PrawatNopporn ThasanaNijsiri RuangrungsiSomsak Ruchirawat
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2006 Volume 54 Issue 2 Pages 262-264

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Abstract

Two new compounds, 3′-(4″-hydroxy-3″,5″-dimethoxyphenyl)-propyl benzoate (1) and 3′-(4″-hydroxyphenyl)-propyl benzoate (3) together with known compounds, 3′-(4″-hydroxy-3″-methoxyphenyl)-propyl benzoate (2), poilaneic acid (4), farnesyl acetone (5) and 4-hydroxybenzaldehyde (6) were isolated and identified from the branches of Croton hutchinsonianus. Their structures were determined by spectroscopic methods. The three phenylpropyl benzoates (1—3) were found to exhibit antifungal activity against Candida albicans (IC50 5.36—11.41 μg/ml). Compounds 1—2 (IC50 2.11—4.95 μg/ml) exhibited potent but non-selective activity against the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) whereas 3 (IC50 1.88 μg/ml) preferentially inhibited the enzyme COX-2.

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© 2006 The Pharmaceutical Society of Japan
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