Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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The Inhibition of Superoxide Anion Generation in Human Neutrophils by Viscum coloratum
Yann-Lii LeuTsong-Long HwangYu-Ming ChungPao-Yun Hong
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2006 Volume 54 Issue 7 Pages 1063-1066

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Abstract

One new 1,3-diphenylpropane, viscolin (1), and one new flavanone, (2S)-7,4′-dihydroxy-5,3′-dimethoxyflavanone (2), together with thirty-nine known compounds, which included eleven known flavanones, two chromones, fourteen benzenoids, one inositol, two pyrimidines, four triterpenoids and five steroids, were isolated and characterized from Viscum coloratum. Structures of new compounds were determined by spectral analysis. Among them, viscolin (1) showed the most significant inhibition on superoxide anion generation by human neutrophils in response to fMLP (formyl-L-methionyl-L-leucyl-L-phenylalanine).

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© 2006 The Pharmaceutical Society of Japan
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