Bioactive Constituents from Chinese Natural Medicines. XXVI. Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis

Seikou Nakamura; Xuezheng Li; Hisashi Matsuda; Kiyofumi Ninomiya; Toshio Morikawa; Kikuji Yamaguti; Masayuki Yoshikawa

doi:10.1248/cpb.55.1505

Regular Articles

Bioactive Constituents from Chinese Natural Medicines. XXVI. Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis

Seikou Nakamura, Xuezheng Li, Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, Kikuji Yamaguti, Masayuki Yoshikawa

著者情報

キーワード: Rhodiolae Radix, Rhodiola sachalinensis, sachaloside, flavonol bisdesmoside, cyanogenic glycoside, hepatoprotective effect

ジャーナルフリー

2007 年 55 巻 10 号 p. 1505-1511

DOI https://doi.org/10.1248/cpb.55.1505

詳細

抄録

The methanolic extract from the roots of Rhodiola sachalinensis was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new glycosides, two monoterpene glycosides, two flavonol bisdesmosides, and a cyanogenic glycoside, were isolated together with 34 known compounds. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, sachalosides III and IV, rhodiosin, and trans-caffeic acid, displayed hepatoprotective effects.

責任著者(Corresponding author)

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