Chemical and Pharmaceutical Bulletin
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Further Cytotoxic Sesquiterpene Lactones from Elephantopus mollis KUNTH
Turibio Kuiate TabopdaJoseph NgoupayoJiawei LiuMuhammad Shaiq AliShamsun Nahar KhanBonaventure Tchaleu NgadjuiBang Luu
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Volume 56 (2008) Issue 2 Pages 231-233

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Abstract

Three new sesquiterpene lactones, (4βH)-5α-hydroxy-8α-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6α-olide (1), (4βH)-8α-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6α-olide (2) and 2,5-epoxy-2β-hydroxy-4α-methoxy-8α-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6α-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1—5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells.

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© 2008 The Pharmaceutical Society of Japan
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