Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Lobophytones H—N, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum
Pengcheng YanZhiwei DengLeen van OfwegenPeter ProkschWenhan Lin
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2010 年 58 巻 12 号 p. 1591-1595

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Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of seven new biscembranoids, named lobophytones H—N (17). Their structures were determined by interpretation of 1D- and 2D-NMR (correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), and nuclear Overhauser effect spectroscopy (NOESY)) spectroscopic data in association with MS and IR data. All compounds were tested for the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, cytotoxicity of mouse peritoneal macrophage, and antibacterial activities.

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© 2010 The Pharmaceutical Society of Japan
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