Chemical and Pharmaceutical Bulletin
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Capsofulvesins A–C, Cholinesterase Inhibitors from Capsosiphon fulvescens
Zhe FangSu Yang JeongHyun Ah JungJae Sue ChoiByung Sun MinMi Hee Woo
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2012 Volume 60 Issue 11 Pages 1351-1358

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Abstract

Activity-directed isolation of the n-hexane and dichloromethane fractions of Capsosiphon fulvescens resulted in the identification of four new glycolipids (13): (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-2-O-(4Z,7Z,10Z,13Z-hexadecatetraenoyl)-3-O-β-D-galactopyranosyl glycerol (1, capsofulvesin A), (2S)-l-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(10Z,13Z-hexadecadienoyl)-3-O-β-D-galactopyranosyl glycerol (2, capsofulvesin B), (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galacatopyranosyl glycerol (3, capsofulvesin C). Compounds 16 exhibited acetylcholinesterase (AChE) inhibitory activities with IC50 values ranging from 50.90 to 82.83 µM, whereas 26 showed butyrylcholinesterase (BChE) inhibitory activities with IC50 values of 114.75–185.55 µM. Although most of the compounds isolated lacked scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO), compound 8 showed ONOO scavenging activity with an IC50 value of 26.23 µg/mL.

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© 2012 The Pharmaceutical Society of Japan
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