Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D2
Naoyuki KotokuKohei MizushimaSatoru TamuraMotomasa Kobayashi
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2013 Volume 61 Issue 10 Pages 1024-1029

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Abstract

Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).

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© 2013 The Pharmaceutical Society of Japan
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