Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
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Crotocascarins I–K: Crotofolane-Type Diterpenoids, Crotocascarin γ, Isocrotofolane Glucoside and Phenolic Glycoside from the Leaves of Croton cascarilloides
Susumu KawakamiKatsuyoshi MatsunamiHideaki OtsukaMasanori InagakiYoshio TakedaMasatoshi KawahataKentaro Yamaguchi
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2015 Volume 63 Issue 12 Pages 1047-1054

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Abstract

From the 1-BuOH-soluble fraction of a methanol (MeOH) extract of the leaves of Croton cascarilloides, crotofolanes: crotocascarins I–K, nor-crotofolane: crotocascarin γ, isocrotofolane glucoside and phenolic glycoside were isolated by a combination of various separation techniques. Their structures were elucidated mainly from the NMR spectroscopic evidence. The structure of crotocascarin K was first elucidated by spectroscopic analysis and then was confirmed by X-ray crystallographic analysis. Its absolute structure was finally determined by the modified Mosher’s method. Isocrotofolane glucoside was found to possess a new skeleton, however, its absolute structure remains to be determined.

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© 2015 The Pharmaceutical Society of Japan
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