Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production
Qinghao JinChul LeeJin Woo LeeDongho LeeYoungsoo KimJin Tae HongJin Sook KimJoo-Hwan KimMi Kyeong LeeBang Yeon Hwang
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Supplementary material

2015 Volume 63 Issue 5 Pages 384-387

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Abstract

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3′-O-methyl-5′-hydroxydiplacol (1), along with 10 known compounds (211). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 16 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 µM.

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© 2015 The Pharmaceutical Society of Japan
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