Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Crotofolane-Type Diterpenoids, Crotocascarins L–Q, and a Rearranged Crotofolane-Type Diterpenoid, Neocrotocascarin, from the Stems of Croton cascarilloides
Susumu KawakamiMasanori InagakiKatsuyoshi MatsunamiHideaki OtsukaMasatoshi KawahataKentaro Yamaguchi
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2016 Volume 64 Issue 10 Pages 1492-1498

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Abstract

From the stems of Croton cascarilloides, further crotofolane-type diterpenoids, named crotocascarins L–Q (1–6), and a rearranged one (7), named neocrotocascarin were isolated. Their structures were elucidated from spectroscopic evidence. Also, the structures of crotocascarin O (4) and neocrotocascarin (7) were determined by X-ray crystallographic analyses. As a result, neocrotocascarin (7) was found to possess a new carbon framework. A plausible mechanism for the formation of neocrotocascarin (7) is also discussed.

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© 2016 The Pharmaceutical Society of Japan
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