Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Special Collection of Papers: Regular Articles
Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C–O Axially Chiral Enolates
Keisuke TomoharaKoji KasamatsuTomoyuki YoshimuraTakumi FurutaTakeo Kawabata
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2016 Volume 64 Issue 7 Pages 899-906

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Abstract

Enantioselective intramolecular conjugate addition reactions of short-lived C–O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).

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© 2016 The Pharmaceutical Society of Japan
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