Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Design and Syntheses of Novel Fluoroporphyrin–Anthraquinone Complexes as Antitumor Agents
Gu-Liang YangSheng-Fang ZhaoNian-You ChenShiming Li
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2016 Volume 64 Issue 9 Pages 1310-1314

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Abstract

A novel fluoroporphyrin–anthraquinone hybrid with dipeptide link and its metal complexes were synthesized and evaluated for anti-proliferation activity in human cancer cell line HeLa. The preliminary results demonstrated that all the compounds showed moderate to excellent antitumor activities. Among the active compounds, compound 3 which contains fluorinated porphyrin–anthraquinone and zinc ion exhibited the highest potency with IC50 value of 8.83 µM, indicating that it was a promising antitumor candidate.

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© 2016 The Pharmaceutical Society of Japan
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