Trifasciatosides A–J, Steroidal Saponins from Sansevieria trifasciata

抄録

Four previously unreported steroidal saponins, trifasciatosides A–D (1–4), three pairs of previously undescribed steroidal saponins, trifasciatosides E–J (5a, b–7a, b) including acetylated ones, together with twelve known compounds were isolated from the n-butanol soluble fraction of the methanol extract of Sansevieria trifasciata. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ¹H-NMR, ¹³C-NMR, ¹H–¹H correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), total correlated spectroscopy (TOCSY), nuclear Overhauser enhancement and exchange spectroscopy (NOESY), electrospray ionization-time of flight (ESI-TOF)-MS and chemical methods. Compounds 2, 4, and 7a, b exhibited moderate antiproliferative activity against HeLa cells.