Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Practical Synthesis of Spermine, Thermospermine and Norspermine
Yuka KariyaYuta AsanumaMakoto InaiTomohiro AsakawaKyoko Ohashi-ItoHiroo FukudaMasahiro EgiToshiyuki Kan
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2016 Volume 64 Issue 9 Pages 1403-1407

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Abstract

Polyamines, such as spermine (1), thermospermine (2) and norspermine (3), are widely distributed in nature, and have multiple biological activities. In addition, many of their conjugates have potential for pharmacological use. Here, we present a solid-phase synthesis using our nitrobenzenesulfonyl (Ns) strategy, which can provide 1, 2 and 3 on a gram scale. This approach should be suitable for facile construction of a diverse library of polyamines.

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© 2016 The Pharmaceutical Society of Japan
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