Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Asymmetric Conjugate Additions of Carbonyl Compounds to Nitroalkenes under Solvent-Free Conditions Using Fluorous Diaminomethylenemalononitrile Organocatalyst
Shin-ichi HirashimaTakafumi NarushimaMasahiro KawadaKosuke NakashimaKaori HanaiYuji KosekiTsuyoshi Miura
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2017 Volume 65 Issue 12 Pages 1185-1190

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Abstract

The novel fluorous organocatalyst bearing a diaminomethylenemalononitrile motif is prepared. The fluorous organocatalyst efficiently promotes asymmetric conjugate additions of ketones to nitroalkenes and results in high yields of these addition products with excellent enantioselectivities under solvent-free conditions.

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© 2017 The Pharmaceutical Society of Japan
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