Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Review
i-Motif-Binding Ligands and Their Effects on the Structure and Biological Functions of i-Motif
Shadi Sedghi MasoudKazuo Nagasawa
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2018 Volume 66 Issue 12 Pages 1091-1103

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Abstract

The i-motif is a high-order DNA structure formed by hemiprotonated cytosine–cytosine base pairs under acidic conditions. It is less well studied than other high-order DNA structures, such as G-quadruplexes. However, increasing numbers of i-motif-binding ligands are being reported, and they are being used as tools to investigate the i-motif’s structure and biological functions. It has become clear that the i-motif has a functional role in the regulation of gene expression. In this review, we provide an overview of i-motif ligands so far reported, and we summarize their effects on the structure and their use as tools to investigate its biological functions.

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© 2018 The Pharmaceutical Society of Japan
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