Organocatalytic Direct α-Selective N-Glycosylation of Amide with Glycosyl Trichloroacetimidate

Abstract

Through the synergistic catalytic effect of the halogen bond (XB) donor and thiourea catalyst, a direct α-selective N-glycosylation of the amide residue of asparagine derivative was achieved using readily accessible glycosyl trichloroacetimidate. n-Butyl methyl ether was found to be the most suitable solvent for the α-selectivity.

Graphical Abstract