Chemical and Pharmaceutical Bulletin
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Improving the Solid-State Photostability of Furosemide by Its Cocrystal Formation
Reiko Teraoka Toshiro FukamiTakayuki FuruishiHiromasa NagaseHaruhisa UedaChisato TodeReiko YutaniShuji KitagawaToshiyasu Sakane
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2019 年 67 巻 9 号 p. 940-944

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The photostability of three types of furosemide (FUR) cocrystal (FUR-caffeine, FUR-urea, and FUR-nicotinamide cocrystals) was studied under irradiation with a D65 fluorescent lamp. The coloration of the FUR-urea pellets was significantly faster than that of the intact FUR, whereas the coloration of FUR-nicotinamide was suppressed compared with that of intact FUR and the other cocrystals. In the case of FUR-urea, the chemical degradation of FUR increased by approximately 6.6% after irradiation for 90 d. On the other hand, FUR-nicotinamide showed better chemical stability, with only 1.3% of FUR degraded, which was significantly lower than the other cocrystals. The FUR-urea pellets showed a UV-Visible absorption spectrum similar to that of intact FUR, while the absorption range of FUR-nicotinamide shifted to a shorter wavelength. The light sensitivity of FUR-nicotinamide was improved because of the much lower emission of the D65 fluorescent lamp in the absorption range of the cocrystal.

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© 2019 The Pharmaceutical Society of Japan
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