Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Review
Chemical Research on Antitumor Isoquinoline Marine Natural Products and Related Compounds
Naoki Saito
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2021 Volume 69 Issue 2 Pages 155-177

Details
Abstract

The biologically active, naturally occurring 1,2,3,4-tetrahydroisoquinoline-quinone (THIQ) family members isolated from Actinomycetes and marine organisms have been studied thoroughly over the past five decades. Among them, marine natural products along with their reduced compounds, such as renieramycins and ecteinascidins, have attracted interest due to their fantastic structures and meager availability in nature as well as their potent antitumor profiles. As part of our search for new anticancer metabolites through the isolation and characterization of anticancer THIQ compounds from Thai marine animals, we have developed a fascinating THIQ natural product chemistry and medicinal chemistry based on knowledge of the chemistry of saframycin antibiotics as well as their isolation, characterization, transformation, partial synthesis, and total synthesis. This review mainly presents our contributions during 1999–2019 to the field of research on biologically active renieramycin along with ecteinascidin marine natural products.

Graphical Abstract Fullsize Image
Information related to the author
© 2021 The Pharmaceutical Society of Japan
Next article
feedback
Top