Pharmaceutical Bulletin
Online ISSN : 1881-1345
Print ISSN : 0369-9471
ISSN-L : 0369-9471
Antibacterial Activity of Compounds possessing a Tricarbonylmethane Group. XI. Synthesis of a Compound having Structure analogous to A-Ring of Tetracycline.
Tyunosin UkitaKiichi Arakawa
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JOURNAL FREE ACCESS

1957 Volume 5 Issue 6 Pages 535-538

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Abstract

Two synthetic routes to a compound having the structure analogous to the A-ring of tetracycline, 2-phenylcarbamoyl-5, 5-dimethyl-6-(1-piperidyl)-1, 3-cyclohexanedione, were established. The desired compound was obtained by amination of 2-phenylcarbamoyl-5, 5-dimethyl-6-bromo-1, 3-cyclohexanedione with piperidine. The antibacterial properties of the final product are reported.

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© The Pharmaceutical Society of Japan
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