Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.

Abstract

Both ether and ester glucuronides of salicylic acid were detected by paper chromatography in the urine of rabbits receiving salicylic acid. The ether glucuronide was isolated as methyl (o-methoxycarbonylphenyl 2, 3, 4-tri-O-acetyl-β-D-glucopyranosid) uronate and the structure was confirmed with the synthetic compound.