4, 5-Substituted Pyridazines. III. Oxidation and Solvolysis of 4-Methyl-3, 6-dichloropyridazine.

抄録

1) 4-Methyl-6-chloro-3-pyridazinol (IIIa) and 5-methyl-6-chloro-3-pyridazinol (IIIb) were obtained from 4-methyl-3, 6-dichloropyridazine (I) by refluxing with glacial acetic acid. 2) 4-Carboxy-6-chloro-3-pyridazinol (II) was formed from 4-methyl-3, 6-dichloropyridazine (I) and 4-methyl-6-chloro-3-pyridazinol (IIIa) by oxidation with potassium dichromate in conc. sulfuric acid and it was led to ester (VI), hydrazide (VII), and amide (VIII) derivatives. 3) 5-Carboxy-6-chloro-3-pyridazinol (IX) was also obtained by similar procedure from 5-methyl-6-chloro-3-pyridazinol (IIIb).